Doctors have managed to make cells taken from human foetuses grow
into fully functional kidneys in a mouse.
The technique could offer a more practical way of helping
patients who need organ transplants.
Thousands in the UK alone are on the waiting list for a new
kidney.
Even if one is found, the patient will have to take
anti-rejection drugs forever.
However, just a small number of specially selected cells taken
from the foetus and transplanted into a mouse were able to carry on
developing and create an entire organ with all its different parts.
No human source
And while the age of the foetal cells required means it would be
impossible to establish a supply from a human source, researchers
achieved the same effect with pig embryo cells.
This might allow replacement organs to grow from pig tissue
without some of the normal problems this might create, such as
rejection of the new organ by the human immune system.
The advance, by doctors at the Weizmann Institute of Science in
Israel, was reported in the latest edition of Nature Medicine.
The technique works because cells were taken from the aborted
foetuses aged between seven and eight weeks, and from pig foetuses
which are only four weeks old.
Early cell
At that time, the foetus is just preparing to develop its
kidneys, and a type of cell called a "kidney precursor".
This is a stem cell, a "master" cell that has the ability to
divide and become all the different types of cell required to form a
fully grown kidney.
Both porcine (pig) and human versions of these cells were taken
and transplanted into mice.
Both types developed into perfect organs at an appropriate size
for a mouse.
They produced urine and were supplied with blood by vessels from
the host.
In addition, there was no dangerous immune response to the new
organs - scientists believe because the cells were taken early in
foetal development, cells which would normally trigger the immune
system were not present.
The researchers involved said that a possible treatment might be
developed within the next few years.
However, while there is growing support for the use of pig organs
in transplantation, some experts still believe there is a tiny risk
that previously unknown viruses could pass into humans and cause
illness.
Professor Robin Weiss, from University College London, UK, said
the potential threat from retroviruses that are actually coded into
the genetic makeup of every pig cell remained even if organs from
adult pigs were not used.
He said: "It's exactly the same, no better or worse.
"Retroviruses are not a huge risk, but it presents a problem, and
it's better to be wise before the event."